Ronda Pharm
Ronda Pharm
Synthesis Project

Optimization of a Chelating Intermediate Synthesis Process

A partner company was facing low yields and excessively long reaction times in the production of a key intermediate for contrast agents. The goal was to redefine the synthetic flow to increase efficiency and scalability.

Main Challenge

The conventional process involved 5 separate steps, with the need for isolation and purification after each step. This led to cumulative material losses of over 40% and a production cycle of 11 days.

Our Approach

We designed a cascade "one-pot" synthesis strategy, where three key steps were performed sequentially in the same reactor, without isolating the intermediates. We implemented real-time monitoring of critical parameters (pH, temperature) for precise reaction control.

Implementation & Results

Technical Implementation

  • Redesign of the synthetic pathway for "one-pot" compatibility.
  • Integration of Process Analytical Technology (PAT) sensors for automated feedback.
  • Process validation in a GMP pilot environment.
  • Complete documentation for technology transfer to industrial scale.

Achieved Results

+75%
Final yield
-60%
Production cycle time

Project Conclusion

The project demonstrated that optimization through step consolidation and advanced analytical control can transform a costly industrial process into a competitive and sustainable one, without compromising the final product purity (>99.8%).

Feedback from Partners

Our collaborators appreciate the practical results obtained by integrating our technologies into their production and logistics workflows.

AS

Andrei Sava

Production Director, BioSynth SRL

"The implementation of the sterile environment quality control system reduced process errors by 40% in the first quarter. The precision and reliability are exceptional."

Project: Intermediate compound synthesis for API

MC

Maria Cazan

Head of Logistics, ChemLogistica SA

"The controlled distribution chain management solution optimized our delivery times by 25%. Transparency in batch tracking is now total."

Project: Dedicated logistics platform integration

VP

Vlad Popescu

Chief Process Engineer, IndChimProiect

"The implemented chemical synthesis technology increased the yield of our main process from 78% to 92%. A remarkable qualitative leap."

Project: Reactor optimization for industrial production

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